Vitamin B12 deficiency may occur in between 40% to 80% of the vegetarian population who are not also consuming a vitamin B12 supplement.In Hong Kong and India, vitamin B12 deficiency has been found in roughly 80% of the vegan population as well
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These effects, observed in animal models, have been linked to improvements in muscle physiology and cardiac performance
Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation